HORDB

ID: hor004135
Uniprot ID: Q762I5
Protein name: Resistin
Gene name: Retn
Organism: Bos taurus (Bovine)
Family: Resistin/FIZZ family
Source: Animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Bos (genus), Bovinae (subfamily), Bovidae (family), Pecora (infraorder), Ruminantia (suborder), Artiodactyla (order), Laurasiatheria (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007165 signal transduction; GO:0050996 positive regulation of lipid catabolic process
GO CC: GO:0005576 extracellular region; GO:0005615 extracellular space

Sequence: QSLCPIDKAISEKIQEVTTSLVPGAVRIIGLDCRSVTSRGSLVTCPSGFAVTGCTCGSACGSWDVRAETTCHCQCAGMDWTGARCCRLHIQ
Length: 91(19-109)
Propeptide: MKALSFLFIPVLGLLVCGQSLCPIDKAISEKIQEVTTSLVPGAVRIIGLDCRSVTSRGSLVTCPSGFAVTGCTCGSACGSWDVRAETTCHCQCAGMDWTGARCCRLHIQ
Signal peptide: MKALSFLFIPVLGLLVCG
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells. Potentially links obesity to diabetes.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor004135_AF2.pdb

hor004135_ESM.pdb

Mass:	1117157	Formula:	C398H653N121O128S12
Absent amino acids:	NY	Common amino acids:	C
pI:	7.54	Basic residues:	10
Polar residues:	38	Hydrophobic residues:	28
Hydrophobicity:	18.46	Boman Index:	-11354
Half-Life:	0.8 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	77.14
Instability Index:	3761.32	Extinction Coefficient cystines:	11625
Absorbance 280nm:	129.17